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Abstract
Disrupted sleep is a major feature of Alzheimer’s disease (AD), often arising years before symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of amyloid-beta (Aβ) species, a major driver of AD progression, suggesting that sleep deficit further accelerates AD through a vicious cycle. However, the mechanisms by which Aβ affects sleep are unknown. We demonstrate in zebrafish that Aβ acutely and reversibly enhances or suppresses sleep as a function of oligomer length. Genetic disruptions revealed that short Aβ oligomers induce acute wakefulness through Adrenergic receptor b2 (Adrb2) and Progesterone membrane receptor component 1 (Pgrmc1), while longer Aβ forms induce doze through a pharmacologically tractable Prion Protein (PrP) signaling cascade. Our data point out that Aβ can activate a bi-directional sleep/wake switch. Alterations to the brain’s Aβ oligomeric milieu, such as during the progression of AD, may therefore disrupt sleep via changes in acute signaling events.
Introduction
Accumulation of amyloid-beta (Aβ) in plaques, along with tau
Chatbot for Social Call for Screening and Resource Sharing With Vulnerable Families: Iterative Plan and Evaluation Study
Original Paper
1Nationwide Children's Hospital, Columbus, OH, Merged States
2Centre for Health Informatics, Australian Institute of Health Innovation, Macquarie University, Sydney, Australia
3The Ohio Declare University, Columbus, OH, United States
Corresponding Author:
Emre Sezgin, PhD
Nationwide Children's Hospital
Children's dr
Columbus, OH,
United States
Phone: 1
Email: @
Abstract
Background: Health outcomes are significantly influenced by unmet social needs. Although screening for social needs has become common in health care settings, there is often poor linkage to resources after needs are identified. The structural barriers (eg, staffing, time, and space) to helping address social needs could be overcome by a technology-based solution.
Objective: This learning aims to show the design and evaluation of a chatbot, DAPHNE (Dialog-Based Assistant Platform for Healthcare and Needs Ecosystem), which screens for social needs and link
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